Phase I clinical study of the novel epothilone B analogue BMS-310705 given on a weekly schedule
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چکیده
منابع مشابه
Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study.
The primary aims of this study were to evaluate the timecourse and dose response of microtubule bundle formationin peripheral blood mononuclear cells (PBMCs) and to correlate these data with BMS-247550 pharmacokinetics. The data presented here were obtained from 17 patients enrolled in a Phase I trial who received five dose levels of BMS-247550 (7.4-59.2 mg/m(2)), given as a 1-h infusion once e...
متن کاملPhase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors.
PURPOSE The purpose of this study was to determine the maximum tolerated dose, toxicity, and pharmacokinetics of BMS-247550 administered as a 1-h i.v. infusion every 3 weeks. EXPERIMENTAL DESIGN Patients with advanced solid malignancies were premedicated and treated with escalating doses of BMS-247550. Blood sampling was performed to characterize the pharmacodynamics and pharmacokinetics of B...
متن کاملPhase I study of the farnesyltransferase inhibitor BMS-214662 given weekly in patients with solid tumors.
PURPOSE A phase I trial of BMS-214662, a selective farnesyltransferase inhibitor with significant preclinical antitumor activity in which drug was given as a weekly 1-hour infusion for four of six weeks, was conducted to evaluate the tolerability, pharmacokinetics, and pharmacodynamic effect on farnesyltransferase activity in peripheral blood mononuclear cells. EXPERIMENTAL DESIGN BMS-214662 ...
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to discuss my point, i have collected quite a number of articles, anthologies, and books about "wuthering heights" applying various ideas and theories to this fantastic story. hence, i have come to believe that gadamer and jauss are rightful when they claim that "the individaul human mind is the center and origin of all meaning," 3 that reading literature is a reader-oriented activity, that it ...
15 صفحه اولPhase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design.
PURPOSE BMS-247550 is a semisynthetic derivative of epothilone B with mechanism of action analogous to paclitaxel. It has shown impressive antitumor activity in preclinical studies including in taxane-resistant models. We conducted a phase I trial, based on accelerated titration "2B" design, of BMS-247550 given as a 1-hour infusion every 3 weeks. EXPERIMENTAL DESIGN Seventeen patients (M:F, 1...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2007
ISSN: 0923-7534
DOI: 10.1093/annonc/mdm198